The excellent 2011 cyber-stealth RPG Deus Ex: Human Revolution is headed for the big screen. CBS Films have picked up the rights to develop the game as a film, apparently impressed by the game's sales of 2.5 million copies to date.
Human Revolution was a prequel to two earlier games in the series: Deus Ex (2000), which is frequently-cited as the best RPG (if not the best game) of all time, and Deus Ex: Invisible War (2003), which is not. The game is set in Detroit in 2027, where a former SWAT team member, Adam Jensen, is rebuilt with 'augments', cybernetic implants and limbs which allow him to function after suffering near-fatal injuries. The plot of the game, and presumably the movie, revolves around the tensions over the differences between augmented people and 'normal' citizens, against a backdrop of the rising power of international corporations. The game was highly acclaimed upon release.
Producer Roy Lee encouragingly worked on last year's well-received movie, The Woman in Black. Less encouragingly, his collaborator Adrian Askarieh is responsible for the Hitman movie (which was 'not well-received', to put it mildly) and seems to have a lot of game-to-film adaptations on his plate. The original game designers will be working as consultants, though the level of their work on the movie is open to debate, given they are currently hard at work on Thief 4.