Classic 1981 horror-comedy An American Werewolf in London is being developed as a remake.
The LA Times article about the project is positive about the idea, pointing out the current craze for werewolves and other supernatural creatures should make this a hit and citing the popularity of the horror-comedy subgenre (although the fact they can't think of another successful entry in the field other than the six-year-old Shaun of the Dead is telling). A quick trawl of the Internet reveals that the reaction of most people to the news has been 'negative' to put it mildly.
Part of the problem is that the original American Werewolf achieved its success through its ground-breaking prosthetics and effects work, particularly the werewolf transformation sequence which remains disturbing and impressive thirty years on. For the new film you just know they're going to throw in some CGI and be done with it (although if they did adopt a strict no-CGI approach, I'd be more interested in it). With a witty and impressive script it might be worth a look, but given the quality of recent remakes I'm not holding my breath on this one.