The list is as follows:
- Ron Perlman returns in his familiar role as the narrator.
- Danny Trejo (Spy Kids, Machete) plays Raul the Ghoul, a mechanic.
- Zach Levi (Chuck) plays Arcade, a member of the Followers of the Apocalypse.
- Felicia Day (The Guild, Buffy the Vampire Slayer) is one of the Brotherhood of Steel.
- Matthew Perry (Friends) plays Benny, a fast-talking gangster.
- Kris Kristofferson (Blade, Convoy) is Chief Hanlon, a veteran soldier.
- Rene Auberjonois (Star Trek: Deep Space Nine) is the enigmatic Mr. House.
The game is due for release on PS3, X-Box 360 and PC on 19 October.