The original creative team - writer Simon Furman and artist Andrew Wildman - are returning and the new comic will pick up storylines left dangling back in 1991. Apparently they are ignoring the Generation 2 sequel mini-series that ran in 1993-94, since they feel it hasn't aged as well as the original comics.
Transformers #81 will be released in 2012. The current plan is for a 19-issue arc taking the comic up to #100 and a grand conclusion to the original story begun way back in 1984. Depending on when the exact dates, that could carry them through to the franchise's 30th anniversary in 2014. Needless to say, old-school Transformers fans who still have all of their old comics in a secure drawer (cough) are very pleased by this news.
Simon Furman on what to expect from the new title:
Excellent. Though probably not a hint that the first storyline will be called Shattered Trousers.
"It is going to shatter your trousers! Guaranteed!"